A bio-guided investigation of Mitragyna inermis (Willd) O. Kuntze (Rubiaceae) unveils natural product isolates with potent cross-activity against sensitive and resistant Plasmodium falciparum

Malaria remains a significant global health challenge, especially in sub-Saharan Africa, with rising resistance to artemisinin-based therapies highlighting the urgent need for new, effective, and safer treatments from medicinal plants which have been used by the indigenous people. This study investigates the antiplasmodial potential of natural products from Mitragyna inermis that can combat multidrug resistant P. falciparum.

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