The Bakerlab got the opportunity to visit Pacifichem in 2025. Sam Afoullouss Presenting Solutions From the Past: Exploring the Untapped Potential of Museum Specimens to Preserve Secondary Metabolites Ezequiel Cruz Rosa Presenting Endo-fights: A Study of Secondary Metabolites from Endophytes of the Florida Everglades Sophia Gulisano Presenting The Fungal Pharmacy: Antimicrobials from Endophytic Fungi. Mars English Presenting Mangrove Metabolites: A Study of Secondary Metabolit

In this study, three Antarctic sponges of the genus Latrunculia were investigated, leading to the isolation of five unreported pyrroloiminoquinone alkaloids along with the known metabolite (+)-debromodiscorhabdin A ( 3 ). Three of the new metabolites were brominated, while the other two were found to have a C-5/C-8 sulfur bridge and a C-2/N-18 bridge. Three of the metabolites were shown to have a phenyl ketone substituent on C-14, not previously reported for discorhabdin deri

Black corals have been poorly studied with respect to their secondary metabolite chemistry. With the aim of discovering new bioactive metabolites, we collected deep-sea black corals from the Irish continental margin. Our analysis of the black coral Phanopathes   sp. yielded three new peptides (maigheotides A-C). Through a combination of 2D NMR, mass spectrometry, and Marfey’s analysis, the absolute configuration of all three structures was elucidated. The maigheotides are cha

Malaria remains a significant global health challenge, especially in sub-Saharan Africa, with rising resistance to artemisinin-based...

Oceanic bathyal benthos harbours extremotolerant microbial species living with low nutrient availability, high hydrostatic pressure, and...

Cancer remains a leading cause of death worldwide, highlighting the urgent need for novel and more effective treatments. Natural...

Antibiotic resistance is a major health concern. We now have several harmful microbes that have evolved into versions unaffected by...

New technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a...

Chemical investigation of the Antarctic sponge Suberites sp. has previously led to the identification of new suberitane derivatives, some...

We are thankful for getting the honor to be on the cover of the November 2024 Organic Letters Journal!

Chemical investigation of extracts from the Irish deep-sea soft coral Anthothela grandiflora revealed cadinene-like sesquiterpenes,...

Arya Paghdal Interviews our own Dr. Bill Baker on natural Products drug discovery and Isolation. Listen to the podcast here!...

Deep-sea mining threatens the world’s untapped and unknown underwater pharmacies. Read the full article here

(2023) Respiratory syncytial virus (RSV) is a highly contagious human pathogen that poses a significant threat to children under the age...

(2022) Previous chemical investigation of the Irish deep-sea soft coral Duva florida led to the identification of tuaimenal A (10), a new...

(2022) Chemical investigation of an Antarctic deep-water octocoral has led to the isolation of four new compounds, including three...

Sam Afoullouss Completed his B.Sc. in Biopharmaceutical Chemistry at the National University of Ireland Galway. Here he researched the...

From the baker Lab, we wish you a very spooky Halloween!

Located just south of Miami, the florida keys are a wonderful archipelago that is bustling with life and chemistry. In August of 2022 the...