In this study, three Antarctic sponges of the genus Latrunculia were investigated, leading to the isolation of five unreported pyrroloiminoquinone alkaloids along with the known metabolite (+)-debromodiscorhabdin A ( 3 ). Three of the new metabolites were brominated, while the other two were found to have a C-5/C-8 sulfur bridge and a C-2/N-18 bridge. Three of the metabolites were shown to have a phenyl ketone substituent on C-14, not previously reported for discorhabdin deri

Black corals have been poorly studied with respect to their secondary metabolite chemistry. With the aim of discovering new bioactive metabolites, we collected deep-sea black corals from the Irish continental margin. Our analysis of the black coral Phanopathes   sp. yielded three new peptides (maigheotides A-C). Through a combination of 2D NMR, mass spectrometry, and Marfey’s analysis, the absolute configuration of all three structures was elucidated. The maigheotides are cha

Malaria remains a significant global health challenge, especially in sub-Saharan Africa, with rising resistance to artemisinin-based...

Oceanic bathyal benthos harbours extremotolerant microbial species living with low nutrient availability, high hydrostatic pressure, and...

Cancer remains a leading cause of death worldwide, highlighting the urgent need for novel and more effective treatments. Natural...

New technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a...

Chemical investigation of the Antarctic sponge Suberites sp. has previously led to the identification of new suberitane derivatives, some...

Chemical investigation of extracts from the Irish deep-sea soft coral Anthothela grandiflora revealed cadinene-like sesquiterpenes,...

(2022) Cold water benthic environments are a prolific source of structurally diverse molecules with a range of bioactivities against...

(2023) Respiratory syncytial virus (RSV) is a highly contagious human pathogen that poses a significant threat to children under the age...

(2022) Previous chemical investigation of the Irish deep-sea soft coral Duva florida led to the identification of tuaimenal A (10), a new...

(2022) Nature has been always a great source of possible lead compounds to develop new drugs against several diseases. Here we report the...

(2022) The western Antarctic Peninsula harbours a diverse benthic marine community where dense canopies of macroalgae can dominate the...

(2022) Chemical investigation of an Antarctic deep-water octocoral has led to the isolation of four new compounds, including three...

(2022) The pairing of analytical chemistry with genomic techniques represents a new wave in natural product chemistry. With an increase...

(2022) The Antarctic marine environment, although rich in life, is predicted to experience rapid and significant effects from climate...

Bioinformatic and Mechanistic Analysis of the Palmerolide PKS-NRPS Biosynthetic Pathway From the Microbiome of an Antarctic Ascidian