In this study, three Antarctic sponges of the genus Latrunculia were investigated, leading to the isolation of five unreported pyrroloiminoquinone alkaloids along with the known metabolite (+)-debromodiscorhabdin A ( 3 ). Three of the new metabolites were brominated, while the other two were found to have a C-5/C-8 sulfur bridge and a C-2/N-18 bridge. Three of the metabolites were shown to have a phenyl ketone substituent on C-14, not previously reported for discorhabdin deri

Black corals have been poorly studied with respect to their secondary metabolite chemistry. With the aim of discovering new bioactive metabolites, we collected deep-sea black corals from the Irish continental margin. Our analysis of the black coral Phanopathes   sp. yielded three new peptides (maigheotides A-C). Through a combination of 2D NMR, mass spectrometry, and Marfey’s analysis, the absolute configuration of all three structures was elucidated. The maigheotides are cha

Malaria remains a significant global health challenge, especially in sub-Saharan Africa, with rising resistance to artemisinin-based...

Oceanic bathyal benthos harbours extremotolerant microbial species living with low nutrient availability, high hydrostatic pressure, and...

Cancer remains a leading cause of death worldwide, highlighting the urgent need for novel and more effective treatments. Natural...

Stine graduated with her Bachelor of Science degree in Chemistry from the Florida Institute of Technology in May 2021. During her...

Antibiotic resistance is a major health concern. We now have several harmful microbes that have evolved into versions unaffected by...

New technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a...

Chemical investigation of the Antarctic sponge Suberites sp. has previously led to the identification of new suberitane derivatives, some...

We are thankful for getting the honor to be on the cover of the November 2024 Organic Letters Journal!

Chemical investigation of extracts from the Irish deep-sea soft coral Anthothela grandiflora revealed cadinene-like sesquiterpenes,...

Arya Paghdal Interviews our own Dr. Bill Baker on natural Products drug discovery and Isolation. Listen to the podcast here!...

(2022) Cold water benthic environments are a prolific source of structurally diverse molecules with a range of bioactivities against...

Deep-sea mining threatens the world’s untapped and unknown underwater pharmacies. Read the full article here

Sarah Dietrick is currently a postdoctoral fellow at the University of South Alabama where she studies marine ecotoxicology abd biodiscovery

Sefat earned her bachelor's degree in Pharmacy and master's degree in Pharmaceutical Chemistry from the University of Dhaka in Bangladesh...

Stephanie earned her Bachelor of Science degree in Chemistry, and a Minor in General Public Health, from the University of South Florida...

(2023) Respiratory syncytial virus (RSV) is a highly contagious human pathogen that poses a significant threat to children under the age...

(2022) Previous chemical investigation of the Irish deep-sea soft coral Duva florida led to the identification of tuaimenal A (10), a new...