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A bio-guided investigation of Mitragyna inermis (Willd) O. Kuntze (Rubiaceae) unveils natural product isolates with potent cross-activity against sensitive and resistant Plasmodium falciparum
Malaria remains a significant global health challenge, especially in sub-Saharan Africa, with rising resistance to artemisinin-based...
ezequiel cruz rosa
Aug 151 min read
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Bacterial Diversity in Deep-Sea Sediments of the North Atlantic Ocean and Their Biosynthesis of Secondary Metabolites
Oceanic bathyal benthos harbours extremotolerant microbial species living with low nutrient availability, high hydrostatic pressure, and...
ezequiel cruz rosa
Aug 151 min read
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Unveiling the Mechanism of Action of Palmitic Acid, a Human Topoisomerase 1B Inhibitor from the Antarctic Sponge Artemisina plumosa
Cancer remains a leading cause of death worldwide, highlighting the urgent need for novel and more effective treatments. Natural...
ezequiel cruz rosa
Aug 151 min read
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Stine Olsen
Stine graduated with her Bachelor of Science degree in Chemistry from the Florida Institute of Technology in May 2021. During her...
ezequiel cruz rosa
Jun 61 min read
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IFLScience The Big Questions: Are The Drugs Of The Future Coming From The Deep Ocean?
Antibiotic resistance is a major health concern. We now have several harmful microbes that have evolved into versions unaffected by...
ezequiel cruz rosa
Mar 281 min read
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Anthoteibinenes F–Q: New Sesquiterpenes from the Irish Deep-Sea Coral Anthothela grandiflora
New technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a...
ezequiel cruz rosa
Mar 281 min read
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New Sesterterpenes from the Antarctic Sponge Suberites sp.
Chemical investigation of the Antarctic sponge Suberites sp. has previously led to the identification of new suberitane derivatives, some...
ezequiel cruz rosa
Mar 281 min read
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Front Cover of Organic Letters
We are thankful for getting the honor to be on the cover of the November 2024 Organic Letters Journal!
ezequiel cruz rosa
Nov 11, 20241 min read
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Anthoteibinenes A–E from the Irish Deep-Sea Coral Anthothela grandiflora: An Amination Puzzle
Chemical investigation of extracts from the Irish deep-sea soft coral Anthothela grandiflora revealed cadinene-like sesquiterpenes,...
ezequiel cruz rosa
Sep 4, 20241 min read
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Podcast: Studying for the Scrubs
Arya Paghdal Interviews our own Dr. Bill Baker on natural Products drug discovery and Isolation. Listen to the podcast here!...
ezequiel cruz rosa
Aug 21, 20241 min read
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ezequiel cruz rosa
Dec 15, 20230 min read
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Tuaimenal A, a Meroterpene from the Irish Deep-Sea Soft Coral Duva florida
(2022) Cold water benthic environments are a prolific source of structurally diverse molecules with a range of bioactivities against...
ezequiel cruz rosa
Dec 15, 20231 min read
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These strange underwater animals could save our lives. If we don’t destroy them first.
Deep-sea mining threatens the world’s untapped and unknown underwater pharmacies. Read the full article here
ezequiel cruz rosa
Oct 21, 20231 min read
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Sarah Dietrick
Sarah Dietrick is currently a postdoctoral fellow at the University of South Alabama where she studies marine ecotoxicology abd biodiscovery
ezequiel cruz rosa
Jul 7, 20231 min read
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Sefat E Munjerin
Sefat earned her bachelor's degree in Pharmacy and master's degree in Pharmaceutical Chemistry from the University of Dhaka in Bangladesh...
ezequiel cruz rosa
Jun 6, 20231 min read
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Stephanie Paola Suarez
Stephanie earned her Bachelor of Science degree in Chemistry, and a Minor in General Public Health, from the University of South Florida...
ezequiel cruz rosa
Jun 6, 20231 min read
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Neosuberitenone, a New Sesterterpenoid Carbon Skeleton, from the Antarctic Sponge Suberites
(2023) Respiratory syncytial virus (RSV) is a highly contagious human pathogen that poses a significant threat to children under the age...
ezequiel cruz rosa
Feb 2, 20231 min read
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Tuaimenals B–H, Merosesquiterpenes from the Irish Deep-Sea Soft Coral Duva florida with Bioactivity
(2022) Previous chemical investigation of the Irish deep-sea soft coral Duva florida led to the identification of tuaimenal A (10), a new...
ezequiel cruz rosa
Feb 2, 20231 min read
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From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor
(2022) Nature has been always a great source of possible lead compounds to develop new drugs against several diseases. Here we report the...
ezequiel cruz rosa
Feb 2, 20231 min read
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Amphipod diversity and metabolomics of the Antarctic sponge Dendrilla antarctica
(2022) The western Antarctic Peninsula harbours a diverse benthic marine community where dense canopies of macroalgae can dominate the...
ezequiel cruz rosa
Feb 2, 20231 min read
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